New research suggests that people who discontinue blockbuster GLP-1 drugs like semaglutide or tirzepatide may regain reduced body mass much more quickly than those who halt traditional lifestyle plans.
Findings released in a major medical journal points out that while overweight individuals frequently drop about a fifth of their body weight while on the medication, the mass is regained at an average rate of nearly a kilo each month upon discontinuation.
"Users buying such medications need to be aware of the potential of fast weight regain when the medication ends," warns expert Dr. Susan Jebb.
This pace of regain suggests a return to pre-treatment weight within about 18 months.
Comparing Approaches
The study, which examined dozens of studies involving thousands of participants, contrasted the results of these new drugs with older methods.
Scientists note that people who shed pounds through diet and exercise generally see a more gradual weight regain—perhaps 100 grams monthly—post-intervention.
Explaining the Fast Rebound
Doctors suggest the mechanism of the jabs is key to understanding the heightened regain.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Sustained high doses of the hormone concentrations several times higher than normal may cause the system to produce less of its endogenous hormone, and could diminish responsiveness to its effects," said Dr. Adam Collins, a dietetics specialist.
"Stopping of this hormone supplement means hunger is unsuppressed, making overeating far more likely."
An Ongoing Condition?
The NHS advise the injections for people with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts contend that, due to the significant potential of weight regain, the therapy might need to be long-term.
This perspective is reinforced by pharmaceutical companies, who say that the findings "highlight the chronic character of obesity," similar to managing diseases like diabetes.
Patient Experiences
Individuals who have come off the medication report a intense resurgence of appetite.
"It felt as if a trigger activating and you become ravenous," described an individual.
This challenge is exacerbated if individuals have not established lasting dietary or behavioural modifications during treatment.
Widespread Interest
Recent estimates indicate that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is more common among females than men.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
Finally, researchers emphasize that while these medications are effective tools for weight loss, they are not a standalone fix and long-term success hinges on combined behavioural changes.
